منابع مشابه
New tubulins in protozoal parasites
More than 20 years ago, biochemical analysis of the eukaryotic cell cytoskeleton revealed the major component proteins. The heterodimeric (α/β) protein tubulin was defined as the building block of microtubules, assembled in a polar manner into specifically arranged protofilaments in the microtubule wall [1]. The next two members of the tubulin protein superfamily were both discovered by genetic...
متن کاملTubulins in C. elegans.
The C.elegans tubulin family is composed of nine α-tubulins, six β-tubulins, and one γ- tubulin. Tubulins are highly conserved, functioning as α-β heterodimers that assemble into microtubules. These cylindrical and ubiquitous components of the cytoskeleton are critical for nearly all cellular and developmental processes. C. elegans has provided a model for the study of microtubules in multiple ...
متن کاملProfiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites
Histone deacetylase (HDAC) enzymes work together with histone acetyltransferases (HATs) to reversibly acetylate both histone and non-histone proteins. As a result, these enzymes are involved in regulating chromatin structure and gene expression as well as other important cellular processes. HDACs are validated drug targets for some types of cancer, with four HDAC inhibitors clinically approved....
متن کاملLoss of infectivity of mycobacterial and protozoal exoplasmic parasites after exposure in vitro to the polyenzymic cocktail 'PIGO'.
A myeloperoxidase-mediated oxygen-dependent antimicrobial system has been discovered by Karnovsky, Klebanoff, Rossi, Sbarra, Schultz and their co-workers as the most powerful among several physiological systems that specifically equip the lysosomes of polymorphonuclear leucocytes and endow them with a considerable capacity to destroy micro-organisms after endocytosis (Klebanoff, 1975). Since th...
متن کاملIntestinal Protozoal Parasites in Diarrheal Children and Associated Risk Factors at Yirgalem Hospital, Ethiopia: A Case-Control Study
Aim. A case-control study was conducted to determine the prevalence of G. lamblia, Cryptosporidium, spp and E. histolytica/dispar in diarrheal children at Yirgalem Hospital from February 2011 to August. Subjects and Methods. A total of 230 children participated in the study of which 115 (50%) were cases and 115 (50%) were controls. A single stool sample was collected and examined by direct sali...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2000
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(00)00414-0